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  • BESETTI HEMALATHA. "p21 ras" The hidden target for cancer-An in Silico analysis
    "p21 ras" The hidden target for cancer-An in Silico analysis
    BESETTI HEMALATHA
    p21 ras protein is the most important component involved in the cell multiplication by participating in cell cycle. Due to point mutation in the gene coding p21 ras which ultimately results in the change in some nucleotide bases changing the confirmation of the protein which resulted in the production of altered ras p21 lacking GTP binding activity, which leads to the occurrence of ras p21 in a permanently activated state, causing uncontrolled multiplication of cells.Single nucleotide polymorphisms have been detected in p21 ras which are making the drug binding difficult and reducing the capacities of in binding of p21 ras with ATP_GTP_A motif. The current study focused in silico approach for identification and variation in drug bindings in association with cancer and ADME studies of the best drug.Six mutagenesis 59-T, 83-T, 119-N, 144-I, 164-A, 165-V have been proved to greatly reduce the GTP binding activity to ATP_GTP_A motif.Docking study has proved variations in drug binding...
  • Deepti Mankar. A Clinicopathological Study of Ovarian Tumours
    A Clinicopathological Study of Ovarian Tumours
    Deepti Mankar
    Ovarian cancer is the scourge of Gynaecologists and Histopathologists alike, even today. Notoriously late at first presentation and given the sheer spectrum of possible diagnoses, ovarian tumours have been the focus of intense scrutiny over the last few years. This work is the culmination of an investigation into ovarian oncogenesis in a rural tertiary-care hospital population in Maharashtra, India.
  • A Cancer Battle Plan Sourcebook
    A Cancer Battle Plan Sourcebook
    A Cancer Battle Plan Sourcebook
  • A Cancer Battle Plan
    A Cancer Battle Plan
    A Cancer Battle Plan
  • A fundamental concepts on molecular biology of cancer
    A fundamental concepts on molecular biology of cancer
    As a normal process, our body synthesizes new cells according to the requirement and the cells stop synthesizing new cells when it is not required. In cancer, there is no end for synthesizing new cells. Hence, the uncontrolled growth forms as a mass/tumors of benign, malignant category. Malignant type have the ability to spread. How mutated proto-oncogenes causes cancer and staging of cancers are dealt. Role of mitochondrial enzyme’s, lipid peroxides, inflammation, nitric oxide, NF?B, tumor suppressor protein functions are elaborated. The signaling pathways and its alteration in cancer was highlighted. Cell cycle proteins a major deciding factor that differentiates a cell between normal and abnormal was emphasized. Different apoptotic pathways was explained. The lifestyle of a person-nature of occupation, food, eating habits, exercise etc forms a major criteria in cancer. This disease is only identified at the later stages as it is a symptomless disease except very few type of cancer....
  • Carolyn Goldberg and Deepak Narayan. A New Algorithm for the Management of Dermatofibrosarcoma Protuberans
    A New Algorithm for the Management of Dermatofibrosarcoma Protuberans
    Carolyn Goldberg and Deepak Narayan
    The purpose of this project was to design an algorithm for the management of Dermatofibrosarcom Protuberans (DFSP.) The National Cancer Center Network guidelines suggest immediate reconstruction in most cases after DFSP resection. We believe this algorithm is inadequate. Due to the infiltrating nature of DFSP, tumor margins are often positive after resection. Immediate reconstruction in the context of residual tumor is problematic because of the risk for spreading microscopic disease and the potential to compromise reconstructive options. Here we examined the prevalence of positive margins on permanent pathology after immediate closure following surgical resection of DFSP. Forty percent of patients who underwent immediate closure were found to have positive margins on permanent pathology. Given these findings, we propose a treatment algorithm focused on more conservative surgical management of DFSP in which negative margins are established before closure. Mohs surgery, which allows...
  • Uvani Bodasing. Adherence to HAART for management of Kaposi''s sarcoma
    Adherence to HAART for management of Kaposi''s sarcoma
    Uvani Bodasing
    Adherence outcomes in patients with the most severe complications of AIDS, Kaposi''s sarcoma (KS), the commonest AIDS related cancer, is unknown. This books reports on 35 patients prospectively evaluated over 12 months for adherence to highly active antiretroviral therapy (HAART) in a clinical trial of ARVs for management of AIDS KS in KwaZulu- Natal (KZN). Twenty of the initial patients also recieved Chemotherapy (CXT). Adherence was assessed by 7-day self-report. Patients who reported >95% mean adherence were classified as being adherent to HAART. HIV-1 viral load (VL) and CD4+ cell counts were correlated with adherence to HAART. Mean adherence was 86%.This is the first study to show high adherence rates in patients with AIDS KS, receiving HAART, with and without chemotherapy (CTX), specifically in KwaZulu- Natal South Africa. This experience indicates that adherence to generic fixed-dose combination of stavudine, lamivudine and nevirapine is effective and hold much...
  • George F. Vande Woude. Advances in Cancer Research,103
    Advances in Cancer Research,103
    George F. Vande Woude
    Advances in Cancer Research,103
  • George F. Vande Woude. Advances in Cancer Research,110
    Advances in Cancer Research,110
    George F. Vande Woude
    -
  • George F. Vande Woude. Advances in Cancer Research,v102
    Advances in Cancer Research,v102
    George F. Vande Woude
    Advances in Cancer Research,v102
  • George F. Vande Woude. Advances in Cancer Research,91
    Advances in Cancer Research,91
    George F. Vande Woude
    Advances in Cancer Research,91
  • George F. Vande Woude. Advances in Cancer Research,74
    Advances in Cancer Research,74
    George F. Vande Woude
    Advances in Cancer Research,74
  • George F. Vande Woude. Advances in Cancer Research,92
    Advances in Cancer Research,92
    George F. Vande Woude
    Advances in Cancer Research,92
  • George F. Vande Woude. Advances in Cancer Research,88
    Advances in Cancer Research,88
    George F. Vande Woude
    Advances in Cancer Research,88
  • George F. Vande Woude. Advances in Cancer Research,76
    Advances in Cancer Research,76
    George F. Vande Woude
    Advances in Cancer Research,76
  • Vande Woude Klein. Advances In Cancer Research V84
    Advances In Cancer Research V84
    Vande Woude Klein
    Advances In Cancer Research V84
  • George F. Vande Woude. Advances in Cancer Research,111
    Advances in Cancer Research,111
    George F. Vande Woude
    -
  • George F. Vande Woude. Advances in Cancer Research,99
    Advances in Cancer Research,99
    George F. Vande Woude
    Advances in Cancer Research,99
  • George F. Vande Woude. Advances in Cancer Research,89
    Advances in Cancer Research,89
    George F. Vande Woude
    Advances in Cancer Research,89
  • George F. Vande Woude. Advances in Cancer Research,93
    Advances in Cancer Research,93
    George F. Vande Woude
    Advances in Cancer Research,93

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